AllerPhase: Relief from Seasonal and Perennial Allergies and Asthma

AllerPhase (AllerTrophin™)
Nutritional Support for Relief from Seasonal and Perennial Allergies

All-natural AllerPhase™ is a safe and highly effective herbal formula for rapid relief from seasonal and perennial allergy miseries. The unique proprietary blend of essence herbs quickly and safely relieves allergic symptoms caused by:

A Complex Problem
Allergies begin when the immune system overreacts to a normally harmless substance, such as mold or pollen. Once mistakenly identified as posing a threat to the body the immune system begins to produce antibodies for that substance, setting the stage for future allergic reactions. The next time an allergen is detected the immune system triggers the rapid release of histamine and other inflammatory chemicals from a specialized class of immune cells known as mast cells.

As histamine penetrates local tissues an inflammatory response is triggered, leading to pain, swelling, redness and heat, accompanied by the accumulation and discharge of fluids. This reaction causes most of the common symptoms of respiratory allergy, such as itching of the eyes, nose and throat, watery eyes, sneezing, and a stuffy or runny nose. Left untreated, symptoms can lead to chronic swelling of the sinuses and increased risk of infection.

In addition to attacking the sinuses and eyes, histamine can also affect the throat, lungs, stomach, bladder, vagina, muscles, joints, and central nervous system. Histamine also affects brain tissues, causing inflammation that leads sufferers to feel irritable, confused and unable to concentrate.

A Multi-Herbal Solution for Allergies
Allergies begin when the immune system overreacts to a normally harmless substance, such as mold or pollen. Once mistakenly identified as posing a threat to the body the immune system begins to produce antibodies for that substance, setting the stage for future allergic reactions. The next time an allergen is detected the immune system triggers the rapid release of histamine and other inflammatory chemicals from a specialized class of immune cells known as mast cells.

The best treatment for allergies is to avoid the substances that trigger a reaction. Since this is not always possible, most allergy sufferers turn to prescription and over-the-counter medications for relief. Antihistamines and other drugs may help some patients, but they cause serious problems for many. Typical antihistamines can make even the simplest of tasks, such as driving a car or operating heavy machinery, difficult, or even dangerous. More importantly, simply blocking histamine doesn’t address the real issue, and in time allergy symptoms may become more severe and difficult to treat.

AllerPhase is a unique, proprietary multi-herb formula that offers a natural, yet comprehensive solution to allergy miseries. AllerPhase contains ten traditional Chinese herbs specifically selected for their ability to quickly and safely relieve allergic symptoms while gently resolving the underlying imbalance that trigger allergic disorders.

Rapid Relief From “Brain Fog”
Brain fog is a term used to describe some of the most disabling allergy symptoms, including loss of concentration, impaired memory, irritability, fatigue, exhaustion and poor sleep. Caused by the inflammatory effects of systemic histamine on brain tissues, brain fog severely impairs mental function, contributes to depression and severely degrades the quality of life of people dealing with chronic allergic reactions.

Gastrodia, which appears exclusively in AllerPhase, is largely responsible for the formula’s ability to relieve brain fog. Modern research suggests that gastrodia aids in improving memory by promoting blood flow to the brain. Gastrodia also enhances the ability of other herbs to quickly reach inflamed brain tissues to reduce inflammation, control pain and reduce mental confusion.

Long-Term Support and Recovery
AllerPhase exerts a gentle corrective effect to balance the immune system by dampening the tendency to overreact to allergens. Two special herbs, Paeonia sufruticosa and Pseudostellaria, are included because of their ability to actively support healthy, normal immune function. These two herbs are largely responsible for the formula’s ability to desensitize allergy sufferers to allergens to produce long-term restorative benefits.

Clinical Feedback From Hyla Cass, MD
“As one of the first clinicians to evaluate AllerPhase, I’ve given the formula to numerous patients over the last year. Even in cases where the patient’s allergic symptoms were severe and unresponsive to traditional and alternative therapies, AllerPhase brought about almost immediate and profound relief within 30 to 40 minutes.”

Asthma Relief
“Additionally, the formula has proved surprisingly effective at relieving asthma symptoms. I was out with a friend one evening who is an asthmatic. Suddenly experiencing an asthma attack, she realized that she had forgotten to bring her inhaler with her. I quickly offered her AllerPhase and much to our surprise, her asthma attack was completely stopped in its tracks.”

“All of my allergy patients love AllerPhase, and my professional colleagues are just as impressed as I am with the rapid and safe relief and complete lack of side effects.”

Hyla Cass, MD
Clinical Psychiatrist and author of
8 Weeks to Vibrant Health and
A User's Guide to Herbal Remedies

Clinical Feedback From Ward Dean, MD
“Regarding my experiences with AllerPhase, the first two patients I tried it on both suffered from severe allergies —one with allergic rhinitis, and the other with chronic, low grade asthma that had been misdiagnosed as “bronchitis” by a number of other physicians and treated unsuccessfully by a plethora of antibiotics.”

“The patient with allergic rhinitis was simply blown away by the effectiveness of AllerPhase — she became symptom-free immediately. The patient I diagnosed with asthma also responded rapidly, and her chronic, low grade, unproductive cough ceased immediately.”

“Most significantly was that both of these patients did not require additional treatment, beyond their first bottle.”

Immuno-Normalizing Effect
“Most allergy medications merely relieve the symptoms, to a greater or lesser degree—sometimes with other, unwanted side effects. However with AllerPhase, I not only observed rapid relief of symptoms, but long-lasting relief as well. It appeared that something was going on with these patients’ immune systems as a result of AllerPhase. I interpreted this to be an ‘immune-normalizing’ effect.”

ALS and Lupus
“I then tried AllerPhase on two patients who not only suffered from allergies, but also had severe, disabling autoimmune diseases—one with Amyotropic Lateral Sclerosis (ALS) and the other with Systemic Lupus Erythematosis (SLE).”

“Both of these patients also reported complete elimination of their allergic symptoms. However, even more encouraging, was the reduction of their other disease-related symptoms as well. Both of these patients were on a number of other nutrients, specific for their conditions, so it is not possible to attribute their dramatic turnaround entirely to AllerPhase. However, I believe that AllerPhase was a major contributing factor to their continuing clinical improvement.”

“Amazingly, none of the above patients have so far required a refill of AllerPhase in nearly six months since initiating their therapy.”

Ward Dean, MD
Author of The Neuroendocrine Theory of Aging,
and Smart Drugs and Nutrients, I and
Smart Drugs and Nutrients II

Safety
In addition to a long history of use in Traditional Chinese Medicine for relieving allergic symptoms, the herbs in AllerPhase have been studied and extensively analyzed for safety.

AllerPhase is a non-drowsy formula that doesn’t cause fatigue, fuzzy thinking or pose a danger when driving, as do most antihistamines. And since AllerPhase is not a CNS stimulant, such as pseudo-ephedrine, users note that using the formula does not cause the “wired” sensation typical of certain OTC preparations.

All ingredients are grown and processed under the highest standards of quality assurance, following Good Manufacturing Practice (GMP) regulations, and using only the highest quality herbal ingredients. AllerPhase contains no sugars, salt, yeast, preservatives, artificial flavors or colors, and every batch is certified as free of all drugs and contaminants.

Summary
AllerPhase is the first Western formula to successfully combine a 5,000-year-old Eastern healing tradition with state-of-the-art manufacturing and pharmaceutical-quality processing to finally realize the legendary rejuvenating powers of these healing agents.
AllerPhase presents a simple, natural, and comprehensive solution for immediate relief from allergic symptoms, while generating long-lasting benefit by resolving underlying imbalances that cause allergic reactions in the first place.

A Novel Approach to Effective Allergy Relief
Allergies are an overreaction of the immune system to irritants, called allergens. This overreaction is characterized by inflammation defined as swelling, redness, heat and pain accompanied by exudation of fluids. In upper respiratory allergies, the eyes, sinuses, nose, throat and upper lung tissues may all be inflamed to varying degrees.

The proprietary AllerPhase allergy formula relieves the inflammation while correcting the faulty immune response. The formula is a unique blend of herbs that addresses the various stages of allergic reaction. While each herb addresses immune response and inflammation in some way, various combinations of the herbs attack specific tissue irritations.

Centipeda, Xanthium, and Angelica are well known for their abilities to clear nasal and sinus congestion. Centipeda and Schizonepeta reduce the inflammatory heat that causes itching in the eyes and respiratory tissues. The formula places a unique emphasis on herbs that reduce tissue swelling, the source of much of the misery of allergies, relying on Fritillaria, Angelica, Paeonia, and Platycodon to do this task. As well, another combination of herbs works together to act as an expectorant to get rid of accumulating fluids: Centipeda, Fritillaria, Platycodon, Licorice.

One herb that appears exclusively in AllerPhase is Gastrodia. This herb is traditionally used to treat headaches. Modern research suggests that this herb promotes blood flow to the brain to help improve memory. It is likely that this herb assists the other herbs in quickly reaching inflamed tissues, aids in pain control and helps to clear the “brain fog” that reduces mental function during allergy season.

The other traditional use for Gastrodia is to resolve neurasthenia –nervous exhaustion characterized by a sense of weakness or fatigue, easy exhaustion on the slightest effort, headache, sensitivity to light, inability to concentrate, irritability and complaints of poor memory, poor sleep, numerous constantly-varying aches and pains. These are all common complaints, along with depression, for people with severe and chronic allergic reactions. They are also the most disabling in terms of quality of life – the ability to play, work, and live a full life. Neurasthenia is thought to involve vasomotor disturbances that affect the nerves having control of the blood vessels. Gastrodia is one of the most commonly studied herbs in China for treating hypertension and for improving blood flow in the arteries of the brain.

Finally, two herbs in the blend provide a corrective effect on the immune system that account for the long-term benefits of the formula. Paeonia sufruticosa and Pseudostellaria promote liver and lung function respectively, providing these organs with nutrition to perform their proper immune functions. With many of the herbs in the AllerPhase formula directed to dampening the immune response to allergens, it is important to also support general immune system function. These herbs are likely, along with Gastrodia, to be partly responsible for desensitizing allergy sufferers from their various allergens.

The following chart summarizes the general traditional functions of each of the herbs in AllerPhase in respiratory allergies.

The Allergic Response
From a scientific perspective, the allergic response is very complex, involving thousands of chemical reactions. By understanding the cascade of chemical reactions triggered by various allergens we can further see how the AllerPhase formula interrupts the allergic response in susceptible individuals. Scientific studies on the individual ingredients in AllerPhase support our understanding of the beneficial actions and traditional functions of the formula.
Allergic reactions are triggered by the immune system as it recognizes outside substances or organisms that get into the body. An allergy is a mistake as the immune system reacts to a relatively harmless substance. The part of the immune system that reacts to allergens confuses them with historically harmful parasites and mounts a response that is out of proportion to the danger. For whatever reasons, individuals prone to allergies are known to create abnormally high levels of immunoglobulin E [IgE] antibodies when exposed to allergens that prompt no response in other people.

Physiologically, the allergic response occurs in three stages: sensitization, mast cell activation, and prolonged immune activation.

Stage 1 – Sensitization to Allergens
During Stage 1, when the allergen first meets the immune system, no allergic reaction is produced. Instead, the system gets ready for future encounters with that particular allergen. Cells called macrophages degrade the allergen and display the fragments to T lymphocytes (T cells); T cells secrete interleukin-4, which promotes maturation of B lymphocytes into plasma cells; then plasma cells secrete immunoglobulin E (IgE) antibodies specific for that allergen. These antibodies attach themselves to receptors on mast cells, which come from bone marrow. Mast cells are found in connective tissue throughout the body, especially near the small blood vessels and near epithelial tissue, which covers the skin or lines the respiratory and digestive tracts. IgE antibodies also attach to basophils, a type of white blood cell that can exit the small blood vessels and congregate around invading allergens. The job of the IgE antibodies is to recognize and attach themselves to the allergen at the next exposure.

Stage 2 – The Chemical Cascades Begins
State 2 represents a later encounter between the allergen and the immune system. This second exposure releases a cascade of various chemical reactions that result in acute inflammation of local tissues. The allergen first binds to IgE antibodies on mast cells. The result of this binding is activation of various enzymes that induce mast cell granules to release their contents – substances such as histamine, platelet-activating factor, prostaglandins, and leukotrienes – and these substances trigger the allergy attack by causing inflammation in the local tissues. For example histamine dilates blood vessels causing redness and release of tissue swelling fluids; constricts bronchial tubes, impairing breathing; irritates nerve endings, causing itching and pain; and stimulates production of mucus in the respiratory system. The allergy sufferer experiences sneezing, an itchy, drippy or congested nose, wheezing, coughing, shortness of breath, and even skin swelling, hives or rashes.

Histamine directly contributes to inflammation but its release also begins a chain reaction or chemical cascade that results in the generation of leukotrienes. Histamine activates the enzyme phospholipase A, which in turn releases arachidonic acid--a fatty acid--from the phospholipid membrane of the mast cell. What is then called arachidonate is acted upon by an enzyme called 5-lipoxygenase and converted to an unstable intermediate chemical--leukotriene A--which is immediately metabolized to form either leukotriene B4 or leukotriene C4, D4 or E4. These leukotrienes, especially leukotriene D4, are more than ten times more potent than histamine. In addition to their constricting effect on bronchial muscle, the leukotrienes also act on blood vessels, causing them to become leaky and resulting in the swelling of the skin.

The second family of generated mediators of inflammation – the prostaglandins, or cyclooxygenase products--also has arachidonic acid as their precursor. In this case, however, the arachidonic acid is worked on by the cyclooxygenase enzyme rather than by lipoxygenase. Unlike histamine--which is produced in both mast cells and basophils, prostaglandin D2 (PGD2) is only made in the mast cells. PGD2 is a potent bronchoconstrictor, more powerful than histamine, though less so than the leukotrienes. Elevated PGD2 levels have been measured in secretions aspirated from the lungs of asthmatics and in nasal secretions from patients with nasal allergies. Still, despite high hopes, patients treated with recently developed prostaglandin modifiers have not shown much improvement; in fact, benefits from this theoretically promising new medicine have yet to be documented.

Stage 3 – Prolonged Immune Activation
The immune system can accelerate the initial reaction to an allergen, so the sooner treatment begins the better. The antibodies that detect allergens set off a chain reaction involving armies of cells and chemical signals, calling in more cells and signals. As a result, the allergic reaction can snowball into more severe and widespread symptoms.

Stage 3 is characterized by prolonged immune activation. About half of all patients move into a so-called "late phase" allergic response some 4 to 6 hours later. It is important to act quickly. This late phase is characterized by an influx of inflammatory cells, especially eosinophils but also neutrophils, monocytes and lymphocytes. This inflammatory influx is orchestrated and modulated by a family of cellular factors called cytokines. The synthesis of cytokines by mast cells or basophils is stimulated by the initial allergic reaction; the cytokines are also derived from lymphocytes and other cells that come into play as the reaction continues.

Tissue mast cells and neighboring cells synthesize molecules that induce circulating basophils, eosinophils, and other cells to migrate into that tissue, generating a new wave of symptoms. These recruited cells secrete chemicals of their own that sustain inflammation, recruit other immune cells, and cause local tissue damage. These later phase inflammatory chemicals include newer chemical mediators, further leukotrienes, prostaglandins, thromboxanes, and platelet activating factors that result in chronic inflammation.

More recently, it's been shown that leukotrienes are powerful chemoattractants, recruiting eosinophils and thus contributing to the ongoing allergic inflammation. This may explain why a new family of medications, the leukotriene modifiers, has proven effective in the therapy of mild to moderate asthma.

Several cytokines have been shown to be important in the regulation of IgE synthesis and the accumulation of eosinophils and other inflammatory cells during allergic reactions. The cytokine interleukin 4 (IL-4) has been proven essential for IgE synthesis. IL-4 can also promote the production of IgE antibodies; increased IgE production is the hallmark of allergic disease.

The cytokine interleukin 5 (IL-5) plays a key role in the maturation, activation and survival of eosinophils; increased numbers of eosinophils in the blood and tissues is another characteristic feature of allergic disease. Tumor necrosis factor alpha (TNF-alpha) is another cytokine that is stored preformed within mast cells and is released rapidly after an allergic reaction begins. TNF-alpha regulates the secretion of two additional cytokines, RANTES and eotoxin, which work with IL-5 to attract and activate eosinophils. TNF-alpha also promotes the synthesis of cellular adhesion molecules, which are crucial for inflammatory cell accumulation at the onset of the allergic reaction.

AllerPhase Herbs Inhibit Allergic Reactions
Symptoms of allergy are highly varied, because different allergens stimulate the immune system at different sites in the body. Diverse symptoms and locations require a multiple herb formula but all ingredients addressing inflammation of tissues and reduction of immune response. AllerPhase is the first herbal formula that provides quick-acting symptom relief for upper and lower respiratory allergies while strengthening the immune system to shorten the allergy season.

The goals of anti-allergic treatment are to interrupt the instigation of inflammation [Stage 2], resolve chronic tissue damage [Stage 3], and desensitize the immune system so that it does not overreact to allergens [Stage 1]. Many of the herbs in AllerPhase are able to disrupt the chemical pathways that promote local tissue inflammation. [A variety of different OTC and prescriptive drugs work in this fashion.] While these herbs reduce the acute attacks on the local tissues, other herbs help to clear out the swelling and exudates from chronic inflammation. These herbs are supported by tonic herbs that are able to desensitize the immune system to prevent future allergic reactions. [Less load]

The root of Platycodon grandiflorum has been widely used for the treatment of various chronic inflammatory diseases including airway disease in oriental medicine. The root extract of the plant has been known to be effective in the expectoration of sputum or mucus, thereby improving airway respiratory function and preventing secondary airway inflammation. In this study, we investigated the effect of platycodin D and D3, the saponin components that are anti-inflammatory components in Platycodon grandiflorum. Platycodin D and D3 increased mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization. The effect of platycodin D3 was stronger than that of ATP, a potent mucin secretagogue and also of ambroxole, a mucolytic drug. The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases.

A ll three extracts significantly inhibited the carrageenin-induced edema and the cotton pellet-induced granuloma formation. From these results, it is suggested that KK, H and HS may inhibit both the early exudative stage and the late proliferative stage in inflammatory processes. These extracts are comprised of Platycodon root as do other crude drugs, and the root may be partly responsible for the antiinflammatory effects induced.

The following chart shows the chemicals in the inflammatory chemical pathways that scientific evidence indicates that active ingredients in the herbs in AllerPhase inhibit from causing local tissue inflammation:

References
1. Wen W., China: a new medicine born of tradition. UNESCO Cour. 1979 Jul;7:25-7. PMID: 12309932 [PubMed]
2. Wang SP, Liu XM, Shang WF, Song J, Yu SR, Sun SM. [Effect of Gastrodia on rotation induced motion sickness in mice] Space Med Med Eng (Beijing). 1999 Oct;12(5):342-5. PMID: 12022178 [PubMed]
3. Hayashi J, Sekine T, Deguchi S, Lin Q, Horie S, Tsuchiya S, Yano S, Watanabe K, Ikegami F. Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, 263-8522, Chiba, Japan. Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation. Phytochemistry. 2002 Mar;59(5):513-9. PMID: 11853746 [PubMed]
4. Hsieh CL, Chiang SY, Cheng KS, Lin YH, Tang NY, Lee CJ, Pon CZ, Hsieh CT. Chang Gung Traditional Chinese Medicine Hospital and Chang Gung University, Graduate Institute of Traditional Chinese Medicine, Kwei-Shan, Taoyuan, Taiwan. Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats. Am J Chin Med. 2001;29(2):331-41. PMID: 11527075 [PubMed]
5. Ha JH, Lee DU, Lee JT, Kim JS, Yong CS, Kim JA, Ha JS, Huh K. Department of Pharmacology, College of Medicine, Yeungnam University, 705-717, Taegu, South Korea. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol. 2000 Nov;73(1-2):329-33. PMID: 11025174 [PubMed]
6. Hsieh MT, Peng WH, Wu CR, Wang WH. Institute of Chinese Pharmaceutical Sciences, China Medical College, Taiwan, R.O.C.The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res. 2000 Aug;14(5):375-7. PMID: 10925408 [PubMed]
7. Jingyi W, Yasuhiro M, Naoya H, Seok RC, Yoshiharu Y, Nagara T, Fumiko T, Shigeru M, Junji K. Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan. Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia. J Tradit Chin Med. 1997 Dec;17(4):299-303. PMID: 10437217 [PubMed]
8. Lu SL, Liu X, Wang JL, Ying Q, Hu SG, Hu PP, Zhu GP, Zhen HW, Bai YT, Wang Q. Department of Neurosurgery, Naval Hospital, Shanghai, China. The development of nao li shen and its clinical application. J Pharm Pharmacol. 1997 Nov;49(11):1162-4. PMID: 9401957 [PubMed]
9. Taylor RS, Towers GH. Department of Botany, University of British Columbia, Vancouver, Canada. Antibacterial constituents of the Nepalese medicinal herb, Centipeda minima. Phytochemistry. 1998 Feb;47(4):631-4. PMID: 9461679 [PubMed]
10. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992 May;40(5):1196-8. PMID: 1394633 [PubMed - indexed for MEDLINE]
11. Wu JB, Chun YT, Ebizuka Y, Sankawa U. Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. Biologically active constituents of Centipeda minima: sesquiterpenes of potential anti-allergy activity. Chem Pharm Bull (Tokyo). 1991 Dec;39(12):3272-5. PMID: 1726075 [PubMed]
12. Wu JB, Chun YT, Ebizuka Y, Sankawa U. Biologically active constituents of Centipeda minima: isolation of a new plenolin ester and the antiallergy activity of sesquiterpene lactones. Chem Pharm Bull (Tokyo). 1985 Sep;33(9):4091-4. PMID: 2418993 [PubMed]
13. Hong SH, Jeong HJ, Kim HM. Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University, Iksan, Jeonbuk 570-749, South Korea. Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic reaction in murine model. J Ethnopharmacol. 2003 Oct;88(2-3):229-34. PMID: 12963148 [PubMed]
14. Trakultivakorn M, Kanthawatana S, Tontayapiwat A, Jiraporncharoen K., Department of Pediatrics, Chiang Mai University, Thailand. Comparative study of the pharmacokinetic characteristics of slow release theophylline oral preparations in Thai children with persistent asthma.Asian Pac J Allergy Immunol. 1999 Dec;17(4):255-9. PMID: 10698464 [PubMed - indexed for MEDLINE]
15. Tohda C, Kakihara Y, Komatsu K, Kuraishi Y, Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response. Biol Pharm Bull. 2000 May;23(5):599-601. PMID: 10823672 [PubMed]
16. Shin TY, Jeong HJ, Jun SM, Chae HJ, Kim HR, Baek SH, Kim HM. College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea. Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats. Immunopharmacol Immunotoxicol. 1999 Nov;21(4):705-15. PMID: 10584206 [PubMed]
17. Xiao PG., Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100094, China. A review on the study of hubeimu, Zhongguo Zhong Yao Za Zhi. 2002 Oct;27(10):726-8. PMID: 12776546 [PubMed - indexed for MEDLINE]
18. Prieto JM, Recio MC, Giner RM, Manez S, Giner-Larza EM, Rios JL. Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av. Vicent Andres Estelles, s/n. 46100 Burjassot, Valencia, Spain. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol. 2003 Sep;55(9):1275-82. PMID: 14604471 [PubMed - in process]
19. Ban HS, Lim SS, Suzuki K, Jung SH, Lee S, Lee YS, Shin KH, Ohuchi K. Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan. Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production. Planta Med. 2003 May;69(5):408-12 PMID: 12802720 [PubMed - indexed for MEDLINE]
20. Nam C, Kim S, Sim Y, Chang I. Skin Research Institute, Pacific R&D Center, Yongin, Korea. Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents. Skin Pharmacol Appl Skin Physiol. 2003 Mar-Apr;16(2):84-90. PMID: 12637783 [PubMed - indexed for MEDLINE]
21. Kim DK, Lim JP, Yang JH, Eom DO, Eun JS, Leem KH. College of Pharmacy, Woosuk University, Samrye 565-701, Korea. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9. PMID: 12510838 [PubMed - indexed for MEDLINE]
22. Lin CH, Chang CW, Wang CC, Chang MS, Yang LL. Graduate Institute of Biomedical Technology, Taipei Medical University, Taiwan. Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells. J Pharm Pharmacol. 2002 Sep;54(9):1271-8. PMID: 12356282 [PubMed - indexed for MEDLINE]
23. Oh H, Lee HS, Kim T, Chai KY, Chung HT, Kwon TO, Jun JY, Jeong OS, Kim YC, Yun YG. Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 2002 May;68(5):463-4. PMID: 12058329 [PubMed - indexed for MEDLINE]
24. Kimura Y, Okuda H., 2nd Department of Medicinal Biochemistry, School of Medicine, Ehime University, Japan. Histamine-release effectors from Angelica dahurica var. dahurica root. J Nat Prod. 1997 Mar;60(3):249-51. PMID: 9157191 [PubMed - indexed for MEDLINE]
25. Li H, Dai Y, Zhang H, Xie C. School of Pharmacy, West China University of Medical Sciences, Chengdu. Pharmacological studies on the Chinese drug radix Angelicae dahuricae. Zhongguo Zhong Yao Za Zhi. 1991 Sep;16(9):560-2, 576. PMID: 1804207 [PubMed - indexed for MEDLINE]
26. Wong CK, Leung KN, Fung MC, Fung KP, Choy YM. Department of Biochemistry, Chinese University of Hong Kong, Shatin.The induction of cytokine gene expression in murine peritoneal macrophages by Pseudostellaria heterophylla.Immunopharmacol Immunotoxicol. 1994 Aug;16(3):347-57. PMID: 7798590 [PubMed - indexed for MEDLINE]
27. Wong CK, Leung KN, Fung KP, Choy YM. Department of Biochemistry, Chinese University of Hong Kong, Shatin, 12 Territories. The immunostimulating activities of anti-tumor polysaccharides from Pseudostellaria heterophylla. Immunopharmacology. 1994 Jul-Aug;28(1):47-54. PMID: 7928302 [PubMed - indexed for MEDLINE]
28. Wong CK, Leung KN, Fung KP, Choy YM. Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories. Effects of Pseudostellaria heterophylla on proliferation and differentiation of murine bone marrow cells. Immunopharmacol Immunotoxicol. 1994 Feb;16(1):71-84. PMID: 8169324 [PubMed - indexed for MEDLINE]
29. Lin G, Li P, Li SL, Chan SW. Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, SAR Chromatographic analysis of Fritillaria isosteroidal alkaloids, the active ingredients of Beimu, the antitussive traditional Chinese medicinel herb. J Chromatogr A. 2001 Nov 23;935(1-2):321-38.
30. Lin HC, Ding HY, Wu YC. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China. Two novel compounds from Paeonia suffructicosa. J Nat Prod. 1998 Mar;61(3):343-6. PMID: 9548873 [PubMed - indexed for MEDLINE]
31. Yang HO, Ko WK, Kim JY, Ro HS. Department of Molecular Medicine, Asan Institute for Life Sciences, University of Ulsan, Seoul 138-736, South Korea. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. Fitoterapia. 2004 Jan;75(1):45-9. PMID: 14693219 [PubMed - indexed for MEDLINE]
32. Lee SJ, Lee IS, Mar W. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, Korea. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells. Arch Pharm Res. 2003 Oct;26(10):832-9. PMID: 14609132 [PubMed - in process]
33. Hsiang CY, Hsieh CL, Wu SL, Lai IL, Ho TY. Department of Microbiology, China Medical College, Taichung, Taiwan. Inhibitory effect of anti-pyretic and anti-inflammatory herbs on herpes simplex virus replication. Am J Chin Med. 2001;29(3-4):459-67. PMID: 11789588 [PubMed - indexed for MEDLINE]
34. Ryu G, Park EK, Joo JH, Lee BH, Choi BW, Jung DS, Lee NH. Regional Research Center, Hanbat National University, Taejon, Korea. A new antioxidant monoterpene glycoside, alpha-benzoyloxypaeoniflorin from Paeonia suffruticosa. Arch Pharm Res. 2001 Apr;24(2):105-8. PMID: 11339628 [PubMed - indexed for MEDLINE]
35. Yoshikawa M, Ohta T, Kawaguchi A, Matsuda H. Kyoto Pharmaceutical University, Japan. Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral.Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1327-31. PMID: 10993231 [PubMed - indexed for MEDLINE]
36. Liu F, Ng TB. Department of Microbiology, Nankai University, Tianjin, China. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci. 2000 Jan 14;66(8):725-35. PMID: 10680580 [PubMed - indexed for MEDLINE]
37. Yoshikawa M, Uchida E, Kawaguchi A, Kitagawa I, Yamahara J. Kyoto Pharmaceutical University, Japan. Galloyl-oxypaeoniflorin, suffruticosides A, B, C, and D, five new antioxidative glycosides, and suffruticoside E, A paeonol glycoside, from Chinese moutan cortex. Chem Pharm Bull (Tokyo). 1992 Aug;40(8):2248-50. PMID: 1423794 [PubMed - indexed for MEDLINE]
38. Nagasawa H, Iwabuchi T, Inatomi H., Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.Protection by tree-peony (Paeonia suffruticosa Andr) of obesity in (SLN x C3H/He) F1 obese mice. In Vivo. 1991 Mar-Apr;5(2):115-8. PMID: 1768779 [PubMed - indexed for MEDLINE]
39. Harada M, Yamashita A, Aburada M. Pharmacological studies on the root bark of Paeonia moutan. II. Anti-inflammatory effect, preventive effect on stress-induced gastric erosion, inhibitory effect on gastric juice secretion and other effects of paeonol. Yakugaku Zasshi. 1972 Jun;92(6):750-6. PMID: 5066379 [PubMed - indexed for MEDLINE]
40. Lee KJ, Choi CY, Chung YC, Kim YS, Ryu SY, Roh SH, Jeong HG. Department of Pharmacy, College of Pharmacy, Chosun University, 375 Seosuk-dong, Kwangju 501-759, South Korea. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol Lett. 2004 Mar 7;147(3):271-82. PMID: 15104119 [PubMed - indexed for MEDLINE]
41. Yoon YD, Han SB, Kang JS, Lee CW, Park SK, Lee HS, Kang JS, Kim HM. College of Pharmacy, Chungnam National University, 220 Gung-dong, Yusong-gu, Taejon 305-764, South Korea. Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum. Int Immunopharmacol. 2003 Dec;3(13-14):1873-82 PMID: 14636836 [PubMed - in process]
42. Shin CY, Lee WJ, Lee EB, Choi EY, Ko KH. Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. Planta Med. 2002 Mar;68(3):221-5. PMID: 11914958 [PubMed - indexed for MEDLINE]
43. Lee KJ, Jeong HG. Department of Biology, Chonnam National University, Kwangju, South Korea. Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity. Food Chem Toxicol. 2002 Apr;40(4):517-25 PMID: 11893410 [PubMed - indexed for MEDLINE]
44. Lee KJ, You HJ, Park SJ, Kim YS, Chung YC, Jeong TC, Jeong HG. Department of Biology, Chonnam National University, Kwangju, South Korea. Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett. 2001 Dec 10;174(1):73-81. PMID: 11675154 [PubMed - indexed for MEDLINE]
45. Han SB, Park SH, Lee KH, Lee CW, Lee SH, Kim HC, Kim YS, Lee HS, Kim HM. Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, South Korea. Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int Immunopharmacol. 2001 Oct;1(11):1969-78. PMID: 11606028 [PubMed - indexed for MEDLINE]
46. Choi CY, Kim JY, Kim YS, Chung YC, Seo JK, Jeong HG. Aqueous extract isolated from Platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor-alpha from murine macrophages. Int Immunopharmacol. 2001 Jun;1(6):1141-51. PMID: 11407308 [PubMed - indexed for MEDLINE]
47. Choi CY, Kim JY, Kim YS, Chung YC, Hahm KS, Jeong HG. Department of Pharmacy and Research Center for Proteineous Materials, Chosun University, 375 Seosuk-dong, 501-759, Kwangju, South Korea. Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum. Cancer Lett. 2001 May 10;166(1):17-25. PMID: 11295282 [PubMed - indexed for MEDLINE]
48. Ozaki Y., Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, Tokyo, Japan. Studies on antiinflammatory effect of Japanese Oriental medicines (kampo medicines) used to treat inflammatory diseases. Biol Pharm Bull. 1995 Apr;18(4):559-62. PMID: 7655427 [PubMed - indexed for MEDLINE]
49. Takagi K, Lee EB. Pharmacological studies on Platycodon grandiflorum A. DC. 3. Activities of crude platycodin on respiratory and circulatory systems and its other pharmacological activities. Yakugaku Zasshi. 1972 Aug;92(8):969-73. PMID: 4674417 [PubMed - indexed for MEDLINE]
50. Tian J, Zhu A, Shi J, et al. A double-blind, randomized controlled clinical trial of compound of gastrodine in treatment of mild to moderate vascular dementia in Beijing, China. Presented at the American Heart Association Second Asia Pacific Scientific Forum, Honolulu, Hawaii, June 10, 2003. Abstract # P177.

• • Jan - Feb 2008
• • Nov - Dec 2007
• • Sept - Oct 2007
• • July - Aug 2007
• • May - June 2007
• • Jan - Feb 2007
• • Nov - Dec 2006
• • Sept - Oct 2006
• • Aug 2006

Symptom relieved

Traditional Herb

Inflammatory Chemical

Inflammatory Reaction

Chemical Inhibiting Herb


	Home \| Library \| Newsletter \| Product Guide \| Glossaries \| Resources \| Mailing List \|